The endonuclease domain of the LINE-1 ORF2 protein can tolerate multiple mutations
نویسندگان
چکیده
منابع مشابه
The carboxy-terminal segment of the human LINE-1 ORF2 protein is involved in RNA binding☆
The human LINE-1/L1 ORF2 protein is a multifunctional enzyme which plays a vital role in the life cycle of the human L1 retrotransposon. The protein consists of an endonuclease domain, followed by a central reverse transcriptase domain and a carboxy-terminal C-domain with unknown function. Here, we explore the nucleic acid binding properties of the 180-amino acid carboxy-terminal segment (CTS) ...
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ژورنال
عنوان ژورنال: Mobile DNA
سال: 2016
ISSN: 1759-8753
DOI: 10.1186/s13100-016-0064-x